Inflammation: The Silent Epidemic Impacting Healthy Lifespans

Understand the role of inflammation and how it contributes to declining health and widening disparities in developed countries.

Chronic inflammation and oxidative stress

Chronic inflammation and oxidative stress are interconnected processes that play a significant role in the development and progression of various health conditions. Chronic inflammation is a prolonged inflammatory response that can damage the body’s tissues and organs. It arises from the persistent activation of the immune system, often due to factors like long-term infections, exposure to environmental toxins, poor diet, and lifestyle habits. This ongoing inflammation can lead to a wide range of chronic health-disorders.

Oxidative stress occurs when there’s an imbalance between free radicals (unstable molecules that can damage cells) and antioxidants (molecules that neutralize free radicals) in the body. This imbalance leads to cell and tissue damage, contributing to ageing and the development of many poor-health conditions. Chronic inflammation can exacerbate oxidative stress by producing more free radicals, while oxidative stress can further stimulate inflammatory pathways, creating a vicious cycle that can harm health.

Addressing chronic inflammation and oxidative stress through healthy-lifestyle choices, such as a balanced diet rich in antioxidants, regular physical activity, stress management, and avoiding exposure to harmful substances, can help reduce the risk of related health issues and promote overall well-being.

Comes "Inflamaging", the chronic, low-level inflammation process linked with ageing

“Inflamaging” is a term that combines “inflammation” and “ageing” to describe a concept where chronic, low-grade inflammation contributes significantly to the aging process and the development of age-related conditions. The mechanisms behind inflamaging are complex and involve various factors, including genetic predispositions and lifestyle choices.  This type of inflammation is subtle and systemic, often without the classic signs of acute inflammation such as redness, heat, swelling, and pain. Instead, inflamaging is characterized by the chronic activation of the immune system, leading to a slow but steady damage to tissues and organs over time.

Inflamaging is closely tied to our diet and gut microbiome health. A well-balanced microbiome bolsters immune function and curtails inflammation, while an imbalance can heighten inflammation and hasten aging. Consuming a diet abundant in fruits, vegetables, whole grains, and omega-3 fatty acids aids in sustaining a healthy microbiome, thus fighting inflamaging. These nutrients fortify gut health and lower inflammation. Conversely, processed foods and those laden with sugar and saturated fats can upset microbiome equilibrium and foster inflammation. Adequate nutrition, possibly complemented by thoughtful supplementation, nurtures a healthy microbiome, playing a key role in inflamaging management. This approach is a direct path to bolster health and extend longevity and therefore to manage you overall metabolic health.



Targeting Metabolic Health nutrition interventions for healthier futures

Chrysea is working in developing nutrition interventions guided by key biomarkers, hoping to significantly improve metabolic health by enabling early detection of arising conditions through personalized diets and adequate supplementation. Biomarkers,  which are essentially biological indicators, play a pivotal role in understanding and managing health. They can range from simple metrics like blood glucose levels to highly complex genetic markers. In the context of nutrition, biomarkers serve as a window into the body’s response to various foods, revealing how individual dietary components influence health outcomes. By analyzing these markers, providers can identify potential health-risks or existing conditions, offering a more precise understanding of an individual’s metabolic health. Guided by this insight, nutrition interventions can be highly customized. For instance, someone with a predisposition to hyper-glycemia might receive dietary recommendations aimed at stabilizing blood sugar levels, while another individual with a different set of biomarkers might focus on foods that lower cholesterol. This precision not only enhances the effectiveness of dietary changes but also empowers individuals to make informed choices about their health.