• At BFLS, significant associations reported in a large representative cohort of 8965 Americans between higher spermidine intake levels and lower cardiovascular risk markers were reported to be independent of BMI (Body Mass Index) levels.
• At GRC, significant associations (P<0.05) were reported between lower levels of cardiovascular risk markers and reduced cardiovascular medication use with higher spermidine dietary intake (median 15.8 mg/day).
• AT GRC, results showed that 53 % of nationally representative US study population consumed low levels (< 4.16 mg/day) of dietary spermidine.

Cantanhede, Portugal and Dublin, Ireland; 18 April 2025

In 2024, Chrysea launched Sprevive® – a pure Spermidine formulation — the first in its pipeline of clean and sustainably produced as natural products, developed using a patented precision fermentation process and supported by extensive preclinical and clinical safety data.

Extensive scientific research has long established the critical role of spermidine in activating autophagy, a vital cellular process that removes damaged cells and declines with age. Autophagy is a cornerstone of cellular health, with direct implications for longevity and healthy aging.

The study findings from representative US study populations presented by Chrysea at the 2025 Benjamin Frankin Lafayette Seminar (BFLS) and Gordon Research Conference (GRC) scientific meetingsare consistent with the extensive published preclinical animal and cell model studies indicating that spermidine plays an important role in cardiovascular biology and healthy longevity.

The evidence of low dietary spermidine intake in representative populations suggests that increasing intake by promotion of healthier lifestyles or supplementation may have an important role in supporting cardiovascular health.

“Presentation of these important new results is key to understanding the emerging body of evidence linking higher spermidine intake with cardiovascular biology and health, and the biological mechanisms behind them,” said Dr. Patrick Keohane, Chief Medical Officer at Chrysea. “The field of longevity biotech needs a steady pipeline of high-quality data to guide informed decision-making.”

Sprevive® may offer important biological benefits for the large segment of the population with low dietary intake of spermidine, complementing lifestyle approaches such as exercise to improve both healthspan and lifespan.

Sprevive® is shipping through selected distributors. Chrysea plans to continuously add further claims to the product and expand its availability on a larger scale to various nutrition and other consumer biotech businesses.

For more information, please visit www.chrysealabs.com or contact info@chrysealabs.com

About the BFLS 2025

Founded in 1978 by Alan Epstein (University of Pennsylvania) and Stylianos Nicolaidis (Collège de France) to reunite an international community of researchers in feeding behaviour. To this day, it provides a forum for researchers in the academic, nutritional, and pharmaceutical sectors to learn about and discuss the latest scientific achievements in the field of food intake regulation, appetite control, and feeding behaviour. 

About the GRC The Role of Polyamines in Health and Disease 2025

The Polyamines GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages.

About Autophagy  

Autophagy is your body’s cellular recycling system, and quality control for your cells. Autophagy is essential for a cell to survive and function properly. It is a natural process that recycles damaged cell parts into functioning cell components, removes non-functional cell parts, and can destroy pathogens in a cell that can damage it, like viruses and bacteria.

Autophagy plays an important role when it comes to aging and longevity. As a person ages, autophagy decreases, which can lead to a build-up of intra cellular junk and reduce cell functionality.

About Sprevive®

Sprevive® is the first pure spermidine product produced by a proprietary and sustainable fermentation process. Sprevive® is the first clinically tested in humans  pure spermidine product, with a preclinical regulatory safety package, and recognized by GRAS self-affirmation status for full dose use (20 mg/day). 

Sprevive® is is low-volume, water soluble, allergen-free, gluten-free, protein-free, taste-neutral, and free from contaminants — setting a new gold standard in bioactive supplementation.

About Spermidine

Spermidine is a natural component of our normal diet, with average normal diet intakes reported to be from 4.8 to 17 mg/day.

Extensive pre-clinical model and cell studies have demonstrated biological benefits from supplementation with spermidine, particularly in cardiovascular function but also immune, gastrointestinal function, the microbiome, and metabolic function.  In the past, clinical studies have been hampered by the lack of a pure spermidine product approved for human use and in a form that enables full dosing.

Spermidine is a mediator of autophagy. In 2016, the Nobel Prize in Physiology and Medicine was awarded to Yoshinori Ohsumi for his discoveries of the mechanisms of autophagy and confirming its highly conserved role in maintaining cellular function. Autophagic processes diminish as the human body ages, and the positive effects of spermidine on aging are considered to be due to its action as a natural inducer of autophagy, thus maintaining the body’s healthy aging capacity.

About Chrysea

Chrysea is a biotechnology company revolutionizing the healthcare and wellness industry with precision healthy-lifespan interventions. Leveraging tools of Synthetic Biology and Data Analytics we have unlocked the potential to manufacture products of unparalleled purity at scale, introducing solutions previously inaccessible to industry. Our approach integrates these advanced tools seamlessly into our operations, enabling us to establish a vertically integrated, sustainable business model that spans from laboratory research directly to the consumer. Chrysea’s products are backed by rigorous science-backed clinical research, ensuring pure, safe, functional ingredients and brands that consumers can trust. Join the movement towards a healthier future with Chrysea. #healthylifestyle #precisionhealth #wellnessindustry #sprevive #spermidine.