• For the first time epidemiology study results define normal dietary intake norms and wide range in a large representative cohort of 8965 Americans.
• Significant associations were found between lower levels of cardiovascular risk markers and reduced cardiovascular medication use with higher spermidine dietary intake (median 15.8 mg/day)
• Low dietary spermidine intake is common in the USA.

Cantanhede, Portugal and Dublin, Ireland; 10 April 2025

In 2024, Chrysea launched Sprevive® – a pure Spermidine formulation — the first in its pipeline of clean and sustainably produced natural products, developed using a patented precision fermentation process and supported by extensive preclinical and clinical safety data.

Extensive scientific research has long established the critical role of spermidine in activating autophagy, a vital cellular process that removes damaged cells and declines with age. Autophagy is a cornerstone of cellular health, with direct implications for longevity and healthy aging. But recent published research suggests spermidine’s benefits may extend well beyond autophagy.

The new findings presented by Chrysea at the 2025 American Physiological Society (APS) Summit are consistent with extensive preclinical and epidemiological results indicating that spermidine plays a significant role in cardiovascular health and healthy-lifespan. These insights stem from the first-ever analysis of dietary spermidine intake and its association with cardiovascular risk markers using the comprehensive NHANES (National Health and Nutrition Examination Survey) database.

“Presentation of these important new results is key to understanding the emerging body of evidence linking higher spermidine intake with cardiovascular health benefits and the biological mechanisms behind them,” said Dr. Patrick Keohane, Chief Medical Officer at Chrysea. “The field of longevity biotech needs a steady pipeline of high-quality data to guide informed decision-making.”

Sprevive® may offer important biological benefits for the large segment of the population with low dietary intake of spermidine, complementing lifestyle approaches such as exercise to improve both healthspan and lifespan.

Sprevive® is shipping through selected distributors. Chrysea plans to continuously add further claims to the product and expand its availability on a larger scale to various nutrition and other consumer biotech businesses.

For more information, please visit www.chrysealabs.com or contact info@chrysealabs.com

About the American Physiology Society (APS)

The American Physiological Society connects a multidisciplinary community of scientists and educators from around the world, driving collaboration and spotlighting scientific discoveries in physiology and related disciplines.

About Autophagy  

Autophagy is your body’s cellular recycling system, and quality control for your cells. Autophagy is essential for a cell to survive and function properly. It is a natural process that recycles damaged cell parts into functioning cell components, removes non-functional cell parts, and can destroy pathogens in a cell that can damage it, like viruses and bacteria.

Autophagy plays an important role when it comes to aging and longevity. As a person ages, autophagy decreases, which can lead to a build-up of intra cellular junk and reduce cell functionality.

About Sprevive®

Sprevive® is the first pure (98%) spermidine product produced by sustainable fermentation processes. Sprevive® is the first clinically tested pure spermidine product, with a preclinical regulatory safety package, and recognized by GRAS self-affirmation status for full dose use (20 mg/day). 

Sprevive® is is low-volume, water soluble, allergen-free, gluten-free, protein-free, taste-neutral, and free from contaminants — setting a new gold standard in bioactive supplementation.

About Spermidine

Spermidine is a natural component of our normal diet, with average normal diet intakes reported to be from 4.8 to 17 mg/day.

Extensive pre-clinical model and cell studies have demonstrated biological benefits from supplementation with spermidine, particularly in cardiovascular function but also immune, gastrointestinal function, the microbiome, and metabolic function.  In the past, clinical studies have been hampered by the lack of a pure spermidine product approved for human use and in a form that enables full dosing.

Spermidine is a mediator of autophagy. In 2016, the Nobel Prize in Physiology and Medicine was awarded to Yoshinori Ohsumi for his discoveries of the mechanisms of autophagy and confirming its highly conserved role in maintaining cellular function. Autophagic processes diminish as the human body ages, and the positive effects of spermidine on aging are considered to be due to its action as a natural inducer of autophagy, thus maintaining the body’s healthy aging capacity.

About Chrysea

Chrysea is a biotechnology company revolutionizing the healthcare and wellness industry with

precision healthy-lifespan interventions. Leveraging tools of Synthetic Biology and Data Analytics we have unlocked the potential to manufacture products of unparalleled purity at scale, introducing solutions previously inaccessible to industry. Our approach integrates these

advanced tools seamlessly into our operations, enabling us to establish a vertically integrated,

sustainable business model that spans from laboratory research directly to the consumer. Chrysea’s products are backed by rigorous science-backed clinical research, ensuring pure, safe, functional ingredients and brands that consumers can trust. Join the movement towards a healthier future with Chrysea. #healthylifestyle #precisionhealth #wellnessindustry #sprevive #spermidine.